How Keppra XR<sup>®</sup> Works

Keppra XR® acts by targeting structures in the brain that are not affected directly by most other epilepsy medicines. This video tour* of the brain shows how signals are sent through the nervous system, what causes seizures, and how Keppra XR® can help.

The Science of Keppra XR®
During a seizure, electrical signals in the brain cause the release of chemicals called neurotransmitters. These neurotransmitters help send messages between nerve cells (known as neurons). If the release of neurotransmitters happens too often or goes on for too long, there may be an overload in these electrical signals. This overload can result in a seizure.

Within the neurons, Keppra XR® attaches to specific molecules (called SV2A). These molecules are found on the surfaces of tiny structures in the neurons called vesicles. The attachment of Keppra XR® to the SV2A molecules may help reduce the abnormal spread of signals that can lead to a seizure.

* This depiction is a hypothetical representation of the mechanism of action of Keppra XR® based on available data; many aspects of the neurotransmission process and precisely how Keppra XR® works to control seizures remain unknown.

Next: Taking Keppra XR®

IMPORTANT SAFETY INFORMATION

Keppra XR® is a prescription medicine that is used with other medicines to treat partial onset seizures in people 16 years of age and older with epilepsy.

Keppra XR® is generally well-tolerated, but may not be for everyone. Ask your doctor if Keppra XR® is right for you. Like other antiepileptic drugs, Keppra XR® may cause suicidal thoughts or actions in a very small number of people, about 1 in 500 people taking it. Patients should call their healthcare provider right away if they have depression, mood problems, or suicidal thoughts or behavior while taking Keppra XR®. Keppra XR® may cause extreme sleepiness, tiredness, and weakness, and problems with muscle coordination. Keppra XR® may also cause mood and behavior changes including psychotic symptoms such as hallucinations, delusions, and unusual behavior. Call your healthcare provider right away if you have any of these symptoms. The most common side effects seen with Keppra XR® and other formulations of Keppra® include sleepiness, weakness, dizziness, and infection. Do not stop taking Keppra XR® unless instructed by your healthcare provider. Stopping a seizure medication all at once can cause seizures that will not stop, a very serious problem. Call your doctor for medical advice about side effects. You may also report side effects to FDA at 1-800-FDA-1088 or go to www.fda.gov/medwatch or contact UCB, Inc. at 1-866-822-0068.

Please see Keppra XR® Medication Guide and Full Prescribing Information for additional important patient information.

*With this coupon, you pay the first $25 of your Keppra XR® or Keppra® co-pay and we pay your remaining out-of-pocket expense up to a maximum of $30. This coupon may not be reproduced and must accompany a valid, signed Keppra XR® prescription. No cash value. Offer not valid for prescriptions reimbursed or paid under any government health insurance program (e.g., Medicaid, Medicare) or any private payer in Massachusetts or where otherwise prohibited by law. Patients are responsible for reporting this rebate to any private insurer that covers any part of the prescription. Offer expires on 12/31/12. UCB may cancel or alter this program at any time without notice.