Keppra XR™ offers convenient dosing to help patients stay compliant1,2

  • Simple once-daily dosing available in 500-mg and 750-mg dosage strengths
  • Flexible dosing—can be taken either during the day or night, with or without food
    — Should be taken at the same time every day or night
  • No titration required

Simple dosing

Pills Dosing Chart
  • Effective starting dose: 1000 mg/day (2 × 500-mg tablets once daily)
  • Dosage adjustment: If needed, daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended daily dose of 3000 mg.
  • Missed doses: If a dose is missed, the next dose should not be doubled. If only a few hours have passed since a missed dose, instruct patients to take Keppra XR™ as soon as remembered and return to their regular schedule. If it is almost time for the next dose, instruct patients to resume their regular schedule.
  • Dosing for impaired renal function: Dosing must be individualized according to the patient’s renal function status. See table below.

Keppra XR™ should be gradually withdrawn to minimize the potential for increased seizure frequency.

Convenient dosing encourages compliance1,2

  • Patients taking fewer daily doses are less likely to miss doses and to have breakthrough seizures as a result2
  • Once-daily dosing has been shown to provide the greatest likelihood of compliance1
    — 94% of neurologists agree that an AED should be dosed once daily to promote      compliance and help prevent breakthrough seizures3

Dosing for adult patients with impaired renal function

Simple Dosing Chart

In patients with end-stage renal disease on dialysis, it is recommended that immediate-release Keppra® (levetiracetam) be used instead of Keppra XR™. Please see Keppra® Tablets/Oral Solution Prescribing Information or Keppra® Injection Prescribing Information.


REFERENCES

1. Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouelette VL. How often is medication taken as prescribed?
    A novel assessment technique. JAMA. 1989;261:3273-3277.
2. Cramer JA, Glassman M, Rienzi V. The relationship between poor medication compliance and seizures.
    Epilepsy Behav. 2002;3:338-342.
3. Survey data on file. UCB, Inc.